Which statement about methoxyflurane is NOT true?

Which statement about methoxyflurane is NOT true?

• A. It is the most potent inhalant with slow recovery and up to 50% retention.
• B. It is metabolized for elimination.
• C. It is rapidly eliminated with no tissue retention.
• D. It has high tissue retention.

Answer: (C)

Methoxyflurane’s pharmacokinetic profile centers on high tissue solubility, so it rapidly partitions into tissues and fat rather than staying in the blood. This leads to slow uptake and, after exposure ends, a gradual release from tissues, causing slow recovery and significant tissue retention—often described as substantial storage in body tissues (up to about half of the dose can be retained). Although some methoxyflurane is eliminated by metabolism (liver conversion to fluoride-containing metabolites) and a portion is exhaled, elimination is not rapid and complete; the drug remains in tissues for a prolonged period. Therefore, the statement that it is rapidly eliminated with no tissue retention is not true. The other points align with its known high potency and prolonged recovery due to tissue storage.

Methoxyflurane’s pharmacokinetic profile centers on high tissue solubility, so it rapidly partitions into tissues and fat rather than staying in the blood. This leads to slow uptake and, after exposure ends, a gradual release from tissues, causing slow recovery and significant tissue retention—often described as substantial storage in body tissues (up to about half of the dose can be retained). Although some methoxyflurane is eliminated by metabolism (liver conversion to fluoride-containing metabolites) and a portion is exhaled, elimination is not rapid and complete; the drug remains in tissues for a prolonged period. Therefore, the statement that it is rapidly eliminated with no tissue retention is not true. The other points align with its known high potency and prolonged recovery due to tissue storage.